Tools for calculating radiation dose and risk us epa. Just like for mirdose, users will enter results of kinetic models into the code, which uses them with models of the human body which have been established in the literature to. Pilot pharmacokinetic and dosimetric studies of 18f. Therefore, the code was completely rewritten in the java sun microsystems programming language and was renamed olinda for organ level internal dose assessment. There are many variables that come into play when doing external dose estimation. The olindaexm personal computer code for calculating organ doses and effective. Radiopharmadose, a javabased opensource software for. Claims where it is apparent that a large dose was delivered to the relevant organ can be expedited by performing a partial dose assessment. For some radioisotopes, such as many of those in the actinide series 241am, the plutonium isotopes, etc. Shen s, denardo gl, macey dj, odonnell rt, yuan a, denardo da et al. Olinda calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on usersupplied biokinetic. The authors objective was to compare internal dose estimates obtained using the organ level dose assessment with exponential modeling olindaexm software, the voxel s value technique, and monte carlo simulation. The mird committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. An update of virtualdose software used for assessing.
Organ dosimetry values were calculated by using organ level internal dose assessment software vanderbilt university, 2003 32. Committee on medical internal radiation dose mird snmmi. The new version has been enhanced and includes new human models and nuclides. Dosimetry software such as medical internal radiation dose mirdose 75 or organ level internal dose assessment exponential modeling olindaexm, successor to mirdose, fda 510kapproved device 71 offer users a variety of phantoms that permit calculating radiation doses for individuals at various ages and sizes, and for women at different. Radiation risk may refer to all excess cancers caused by radiation exposure incidence. Radiation exposure of the body and critical organs was calculated from the 18fmk3328 residence times using olinda organ level internal dose assessment software. Radiation dose to patients from radiopharmaceuticals. Olindaexm organ level internal dose assessmentexponential modeling 1 jan 2019 27 jun 2019 olindaexm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004.
The personal computer code olinda, which is an acronym standing for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from radiopharmaceuticals which are administered systemically mostly intravenously, but sometimes by oral or. The olinda exm application is widely used in the radiopharmaceutical industry and research community for internal dose calculations of radiopharmaceuticals. Most of the main functions of mirdose were retained, but some new models were added. Values were calculated from human biodistribution data using olindaexm organ level internal dose assessmentexponential modeling software. Internal dose concepts are employed when radioactive material enters the body through any pathway, either in a workplace situation, in the nuclear medicine clinic where the intakes are quite intentional, from eating or drinking contaminated food and water, and other such situations. After injection of 370 megabecquerel mbq of 18fjnj64326067, a series of wholebody positron emission tomography pet images will be obtained over a period of up to 6 hours and corrected for attenuation by computed tomography ct transmission scans using. Values were calculated from human biodistribution data using olindaexm organ level internal dose assessment exponential modeling software.
Olindaexm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and. The 5ht 2a receptor agonist actions of 11 ccimbi36 in vivo pharmacological effects in mice elicited by increasing doses of cimbi36 were assessed with the headtwitch response htr. Based on animal data, the organ level internal dose assessment software was used to estimate extrapolated human dosimetry for 11ccimbi36. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as an update to mirdose. Olindaexm is a personal computer code for calculating organ doses and effective doses in nuclear medicine studies was developed in 2004. Olindaexm organ level internal dose assessmentexponential modeling. The radioactivity dose 370 to 740 mbq, 10 to 20 mci is chosen based on patient body dimensions and the characteristics of the. Olindaexm radiation dose assessment software application. I was wondering is there any free software similar to olindaexm 2. Early internal and external dose estimation initial version. Axumin fda prescribing information, side effects and uses. In addition, a new section of code was added that allowed users to. The olindaexm personal computer code performs dose calculations and. Radiation dosimetry calculation internal dosimetry estimates were calculated using the organ level internal dose assessment olinda software v.
K03396 by the us food and drug administration as a software device. The effective dose ed per organ will be calculated using organ level internal dose assessment olinda software. The 5ht2a receptor agonist actions of 11ccimbi36 in vivo pharmacological effects in mice elicited by increasing doses of cimbi36 were assessed with the headtwitch response htr. Comparison of internal dose estimates obtained using organlevel. The input parameters required by the olinda software for the estimation of the absorbed dose are the type of radionuclide, a phantom or phantoms, and the number. Epas sciencebased tools help radiation protection professionals calculate radiation dose and risk risk the probability of injury, disease or death from exposure to a hazard. This code was completely rewritten and renamed olinda organ level internal dose assessment stabin et al.
As with the comprehensive dose assessment, the radiation dose from internal sources as a result of either inhalation or ingestion can use pbpk models. Pmod pmod technologies zurich, switzerland, imaging software. Biodistribution and radiation dosimetry of ejnmmi research. A study to investigate the whole body distribution and. For each organ, the equivalent dose, which is the absorbed radiation dose weighted for the degree of the biological effect of different types of radiation, was calculated.
Based on animal data, the organ level internal dose assessment software was used to estimate extrapolated human dosimetry for 11 ccimbi36. Fyi, the predecessor of the olindaexm organ level internal dose assessmentexponential modeling version 1. However, the accuracy for individualized organ dose assessment is still. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as. The code olindaexm, which is an acronym standing for organ level internal dose assessmentexponential modeling, was designed as an update to mirdose. Early internal and external dose magnitude estimation. The organ level internal dose assessment code, olinda, with an exponential modeling exm function, is the update and replacement of the mirdose personal computer software. The radiation absorbed effective dose resulting from the administration of the recommended activity of 370 mbq of axumin is 8 msv. Preclinical voxelbased dosimetry through gate monte carlo.
Among the things to consider are time of exposure, distance from the source, source activity, potential shielding, and isotope. About internal dose assessment in nuclear medicine. Some of these items are usually fairly straight forward, source activity and isotope, for instance. The radiation absorbed doses estimated for adult patients following intravenous injection of axumin are shown in table 1. Ct dose not that small 45 ct scans are used for imageguided radiation therapy igrt a p ding, j w gu, x g xu, trofimov av. Radar software radar the radiation dose assessment. Committee on medical internal radiation dose mird radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. Monte carlo calculation of imaging doses from diagnostic multidetector ct and kilovoltage cone beam ct as part of prostate cancer treatment plans. Practical determination of organ s values for individual patients for therapy.
Olindaexm, which stands for organ level internal dose assessment exponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on usersupplied biokinetic. Mird is listed in the worlds largest and most authoritative dictionary database of. Looking for online definition of mird or what mird stands for. A new tool, named oedipe a french acronym that stands for tool for personalized internal dose assessment was developed to carry out personalized internal dosimetry calculations for nuclear medicine for both therapeutic and diagnostic procedures and for radiation safety in the case of internal contamination. Click here to see some sample screens from the software. Preclinical evaluation of 18ffba20fmdv2 as a selective. Organ level internal dose assessmentexponential modeling version 1. Comparison of internal dose estimates obtained using organ. Organ level internal dose assessmentexponential modeling software from vanderbilt university. The personal computer code olindaexm, which is an acronym standing for organ level internal dose assessment exponential modeling, was designed as an update to mirdose. Thresholded datasets were used to hand draw threedimensional regions of interest over all of the major organs showing visually appreciable uptake greater than that in the background tissue table 2.
Olindaexm, which stands for organ level internal dose assessmentexponential modeling, calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression. This gives a rough estimate of the level of severity of the risk involved from any radiologic examination. Radar medical procedure radiation dose calculator and consent language generator. Eanm dose calculator for clinical radiopharmaceutical administration. Technology olindaexm radiation dose assessment software. These departures from traditional occupational internal dose assessment have created a need for the development of new approaches as well as new software to accomplish the goal. The preferred dose estimate from an individual risk assessment is the annual absorbed organ dose. Tools for calculating radiation dose and risk epa bases its radiation protection activities on scientific assessment of health risks posed by radioactive substances. Mirdose outdated by olindaexm organ level internal dose assessmentexponential modeling olindaexm online calculators. Epa bases its radiation protection activities on scientific assessment of health risks posed by radioactive substances. Preclinical safety assessment of the 5ht 2a receptor. Epas sciencebased tools help radiation protection professionals calculate radiation dose and risk riskthe probability of injury, disease or death from exposure to a hazard. Vu0338olindaexm radiation dose assessment software. In this study, radiation absorbed doses and effective doses were calculated based on the radar method by entering the timeintegrated activity coefficient formerly known as residence time of each source organ into olindaexm 1.
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